Steam loco wheels have to be 'quartered'. In simple terms, looking at the right side drivers, if all of the screw holes are at the "3 O'clock' position, the screw holes on the left side should all be straight up at "12 O'clock". If not, you'll get binding. The wheels are press fit on the axles, so i something is off, it's usually a simple matter to twist things back into alignment.
Len
Len