I just got a 2-4-4-2 and on my layout I run mostly 0-4-2 Porters so my minimal radius is 10.5 inches. I've run the Porters all the way down to 8 inch radius. I have 18 and 22 inch radius curves on a couple spots on the layout. I tried the 2-4-4-2 at slow speed through the layout, no problems on the 18 or 22 inch curves and was able to make one of the 10.5 radius curves and had trouble with the second 10.5 radius curve. The second one was the last one put in and might not be as well laid as the first. I'm going to redo it and see if that helps.
You may not have the same results as I did.
You may not have the same results as I did.